March 11, 2025

NovaISM: Advancing FLIM with Super-Resolved Spatial Details and Enhanced Contrast

New Image Scanning Microscopy analysis software for the Luminosa confocal microscope

NovaISM interface showing ISM reconstruction and FLIM analysis tools

PicoQuant introduces NovaISM, a cutting-edge software for Fluorescence Lifetime Imaging Microscopy (FLIM) and Image Scanning Microscopy (ISM) that delivers super-resolved spatial details and improved contrast. Designed for seamless integration with the Luminosa microscope, NovaISM is optimized for the PDA-23 SPAD array, enhancing FLIM imaging with unparalleled precision. Key features include pixel reassignment, which refines spatial resolution, and deconvolution, which restores fine details and reduces noise. These improvements ensure sharper optical sectioning and better signal quality, allowing researchers to extract more information from every photon. With NovaISM, FLIM users can achieve a new level of clarity in cellular biophysics, protein interactions, and metabolic imaging.

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