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News and Press Releases

November 6, 2023

Streamlined Single-Molecule FRET and FCS Measurements for Structural Biology and Phase Separation Studies

Webinar on demand now available

Quantitative single-molecule and time-resolved fluorescence techniques offer new insights into many samples from various research areas such as dynamic structural biology, cellular mechanisms driven by phase separation, and virology. Using examples from these areas, Dr. Maria Loidolt-Krüger shows how single-molecule FRET (smFRET), fluorescence (cross-)correlation spectroscopy, and time-resolved anisotropy can be combined to get a comprehensive picture of the sample under investigation.

In order to get reliable, quantitative results, many factors like laser power, or spectral bleed-through need to be considered. These will be discussed, together with ways to increase the accuracy and reproducibility of experiments, with a focus on smFRET studies. Ultimately, findings from in vitro studies need to be linked to studies in cells and tissues. Maria showcases how this can be achieved by taking FCS into cells, and by going from smFRET to FRET imaging, and from time-resolved anisotropy to anisotropy imaging.

The presentation is available on demand on our website.

Streamlined Single-Molecule FRET and FCS Measurements for Structural Biology and Phase Separation Studies

October 4, 2023

Nobel Prize in Chemistry awarded to pioneers of quantum dot discovery

Some examples for the characterization of quantum dots using PicoQuant instrumentation

Moungi G. Bawendi, Louis E. Brus, and Alexei I. Ekimov received this year's Nobel Prize in Chemistry for the discovery and synthesis of quantum dots. We are excited to celebrate this remarkable accomplishment and express our heartfelt congratulations to the laureates.

We also take pride in our contribution to their research journey. Our cutting-edge time-resolved luminescence spectrometers and microscopes enable scientists worldwide to investigate the photophysical characteristics of quantum dots and their unusual properties determined by quantum phenomena.

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Nobel Prize in Chemistry awarded to pioneers of quantum dot discovery

September 27, 2023

PicoQuant’s commitment to sustainable consumption: extending the lifespan of scientific systems

A 21-year-old MicroTime 200 microscope receives comprehensive upgrade

Extending product lifespan is considered to be most effective way towards sustainable consumption. With this in mind, we at PicoQuant design our systems so that they can be repaired and upgraded for a long time, enabling cutting-edge research for many years.

Here is one example: The second MicroTime 200 fluorescence microscope ever sold, which was installed in 2002, received a comprehensive upgrade, breathing new life into a two-decade-old system at the Instituto Superior Técnico, in Lisbon, Portugal. It is wonderful to see that a system sold 21 years ago is still operational in the lab of Prof. Sílvia Brito Costa and Pedro Paulo and can be serviced by us.

PicoQuant’s commitment to sustainable consumption: extending the lifespan of scientific systems

September 19, 2023

PicoQuant’s global reseller network gathers virtually for dynamic training event

Collaboration, innovation, and success stories are the central topics of the meeting

Last week, we brought together our incredible network of resellers from across the globe for a dynamic virtual training event. It was a great opportunity to collaborate with partners who share our passion for cutting-edge photonics solutions. We unveiled exciting news and introduced innovative new products. Live demos showcased the power and capabilities of our current product line-up. Our Product Managers engaged in insightful discussions with our resellers, ensuring we're aligned with our customers' needs. We fostered a platform for the exchange of best strategies and success stories to conquer the competition.

Thank you to our dedicated resellers for their unwavering commitment and to the entire PicoQuant sales team for making this event a success!

PicoQuant’s global reseller network gathers virtually for dynamic training event

September 15, 2023

Multiplexing 9 fluorescent proteins in one shot

Multicolor PIE-FLIM and pattern matching analysis visualize HIV-1 uptake into living cells

Dissecting multi-step biological processes such as HIV entry into host cells requires fluorescent labeling and simultaneous imaging of many targets, for example virus components and host cell organelles. To overcome this challenge, Tobias Starling and colleagues from Sergi Padilla-Parra's lab at King's College London unleashed the full power of PIE-FLIM with their MicroTime 200 microscope: They imaged 9 FPsfluorescent proteins at once with three lasers and three detectors.

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Multiplexing 9 fluorescent proteins in one shot